This theme advances living multifunctional materials into real-world contexts by integrating them into complex systems and targeted applications. Research spans the built environment and adaptive infrastructure, where responsive materials enhance resilience in buildings and cities, and aerospace and mobility, where lightweight, multifunctional systems enable next-generation vehicles. We explore soft robotics and autonomous systems that couple material intelligence with adaptability, and prioritize environmental monitoring and remediation to address urgent challenges in sustainability and planetary health. Applications also extend to biomedical technologies, where materials interface with the human body to support healing and function, and to brain-inspired and neuromorphic computing networks, where material systems emulate cognition to drive new paradigms in computation. Together, these domains demonstrate how LiMC² research moves from fundamental discovery to transformative impact across society.